发明授权
- 专利标题： Transdermal drug delivery using an osmolyte and vasoactive agent
- 专利标题（中）： 使用渗透液和血管活性剂的透皮药物递送
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申请号： US12564841申请日： 2009-09-22
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公开(公告)号： US09566256B2公开(公告)日： 2017-02-14
- 发明人: Stephen G. Carter , Zhen Zhu , Kanu Patel , John J. Masiz
- 申请人： Stephen G. Carter , Zhen Zhu , Kanu Patel , John J. Masiz
- 申请人地址： US MA Danvers
- 专利权人： Biochemics, Inc.
- 当前专利权人： Biochemics, Inc.
- 当前专利权人地址： US MA Danvers
- 代理机构： Sunstein Kann Murphy & Timbers LLP
- 主分类号： A61K47/26
- IPC分类号： A61K47/26 ; A61K31/192 ; A61K31/415 ; A61K9/00 ; A61K9/06 ; A61K31/05 ; A61K31/19 ; A61K31/426 ; A61K45/06 ; A61K47/02 ; A61K31/455 ; A61K31/427 ; A61K47/22 ; A61F13/00
摘要：
A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.