A method or system detects abnormalities in a biological sample cells. The method or system performs at least the following steps, or is capable to carry out at least the following steps, respectively: a) acquiring an image of the sample by digital image acquisition, b) optionally, carrying out digital image processing, c) selecting a field of view, d) determining, by digital image processing, whether or not, in the field of view, cell aggregates exist, and e1) selecting a new field of view and carrying on with step c) if, in step d), it turns out that, in the field of view, the determination of cell aggregates is negative, or e2) carrying out further process steps if in step d), it turns out that, in the field of view, the determination of cell aggregates is affirmative.