A pressure compensation system is provided. A subsea enclosure of the subsea device encloses the chamber. A first pressure compensator has a first compensation volume and provides pressure balancing between ambient medium surrounding the subsea device and the first compensation volume. A first biasing device is configured to bias the first pressure compensator such that the pressure in the first compensation volume is higher than the pressure in the ambient medium surrounding the subsea device. A second pressure compensator has a second compensation volume and provides pressure balancing between the ambient medium and the second compensation volume. A second biasing device biases the second pressure compensator such that the pressure in the second compensation volume is higher than the pressure in the ambient medium. A control unit is connected to control first and second valves arranged in flow connections between the first and second compensation volumes and the chamber.