发明授权
US09573974B2 Multi-leu peptides and analogues thereof as selective PACE4 inhibitors and effective antiproliferative agents
有权
多肽和其类似物作为选择性PACE4抑制剂和有效的抗增殖剂
- 专利标题： Multi-leu peptides and analogues thereof as selective PACE4 inhibitors and effective antiproliferative agents
- 专利标题（中）： 多肽和其类似物作为选择性PACE4抑制剂和有效的抗增殖剂
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申请号： US14149857申请日： 2014-01-08
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公开(公告)号： US09573974B2公开(公告)日： 2017-02-21
- 发明人: Robert Day , Martin Fugére , Witold A. Neugebauer
- 申请人： LA SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUEE SOCPRA-SCIENCES SANTE ET HUMAINES S.E.C.
- 申请人地址： CA Sherbrooke
- 专利权人： LA SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUEE SOCPRA-SCIENCES SANTE ET HUMAINES S.E.C.
- 当前专利权人： LA SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUEE SOCPRA-SCIENCES SANTE ET HUMAINES S.E.C.
- 当前专利权人地址： CA Sherbrooke
- 代理机构： Norton Rose Canada LLP
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K7/06 ; C07K5/11 ; C07K14/81 ; C12Q1/37
摘要：
Disclosed herein are PACE4 inhibitors, compositions comprising PACE4 inhibitors and their uses thereof for lowering PACE4 activity, reducing cell proliferation, reducing tumor growth, reducing metastasis formation, preventing and/or treating cancer. Also provided are methods for lowering PACE4 activity, reducing the proliferation of a cell, reducing tumor growth and/or treating and preventing cancer. Methods for screening PACE4 inhibitors and cell proliferation inhibitors are further provided.
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