发明授权
- 专利标题: Selective inhibition of polyglutamine protein expression
- 专利标题(中): 选择性抑制聚谷氨酰胺蛋白表达
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申请号: US13575842申请日: 2011-02-03
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公开(公告)号: US09574191B2公开(公告)日: 2017-02-21
- 发明人: David R. Corey , Jiaxin Hu , Dinah W. Y. Sah
- 申请人: David R. Corey , Jiaxin Hu , Dinah W. Y. Sah
- 申请人地址: US TX Austin
- 专利权人: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
- 当前专利权人: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
- 当前专利权人地址: US TX Austin
- 代理机构: Norton Rose Fulbright US LLP
- 国际申请: PCT/US2011/023615 WO 20110203
- 国际公布: WO2011/097388 WO 20110811
- 主分类号: C12N15/11
- IPC分类号: C12N15/11 ; C12N15/113 ; A61K31/713 ; A61K38/17
摘要:
The present invention relates to the selective inhibition of protein expression of CAG repeat-related disease proteins such as Huntingtin Disease Protein and Ataxin-3 using double-stranded RNAs and nucleic acid analogs. Chemically-modified RNAs having at least one mismatch as compared to the target CAG repeat sequence are specifically contemplated.
公开/授权文献
- US20130172399A1 SELECTIVE INHIBITION OF POLYGLUTAMINE PROTEIN EXPRESSION 公开/授权日:2013-07-04
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