Provided are a PUCCH resource configuration method, transmission method, device and system. The method includes: allocating dedicated PRBs for UEs configured to transmit uplink control information using an enhanced PUCCH, which step comprising: taking the UEs configured to transmit the uplink control information using the enhanced PUCCH as a first type of UEs, and taking UEs other than the first type of UEs as a second type of UEs; and reserving a designated number of PRBs according to the number of UEs in the first type of UEs, wherein the designated number of PRBs are located between SR/semi-static ACK/NACK resources of the second type of UEs and dynamic ACK/NACK resources of the second type of UEs, and taking the designated number of PRBs as dedicated PRBs for the first type of UEs; and allocating orthogonal resources for UEs located in different cells among the first type of UEs based on the dedicated PRBs. The disclosure solves the problem of great interference between PUCCH from different cells and ensuring the receiving quality of the PUCCH.