发明授权
- 专利标题: Method and apparatus for preparing novel liposome
- 专利标题(中): 制备新型脂质体的方法和装置
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申请号: US13580236申请日: 2011-02-24
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公开(公告)号: US09579261B2公开(公告)日: 2017-02-28
- 发明人: Sung Joo Hwang , Hee Jun Park , Wonkyung Cho , Kwang-Ho Cha , Junsung Park , Chanhyuk Park , Donggeon Gu
- 申请人: Sung Joo Hwang , Hee Jun Park , Wonkyung Cho , Kwang-Ho Cha , Junsung Park , Chanhyuk Park , Donggeon Gu
- 申请人地址: KR Gyeonggi-do
- 专利权人: BCWORLD PHARM. CO., LTD.
- 当前专利权人: BCWORLD PHARM. CO., LTD.
- 当前专利权人地址: KR Gyeonggi-do
- 代理机构: Quarles & Brady, LLP
- 优先权: KR10-2010-0016555 20100224
- 国际申请: PCT/KR2011/001303 WO 20110224
- 国际公布: WO2011/105835 WO 20110901
- 主分类号: A61J3/07
- IPC分类号: A61J3/07 ; A61K9/127 ; A61K9/19 ; A61K31/70 ; B01D11/04
摘要:
Disclosed is a method for preparing a liposome formulation. In the disclosed method, a lipid fraction is dissolved in an organic solvent. The solution including a bioactive component and the lipid fraction, together with a carrier, is put in a reaction vessel, and a supercritical fluid is introduced thereto, so as to prepare particles coated with the bioactive component-lipid. The supercritical fluid is discharged by compression to obtain proliposome particles, and then the proliposome particles are hydrated by an aqueous solution including water so as to form a liposome solution. Preferably, the formulation may include one or more bioactive components. As required, the liposome formulation may be further processed by methods such as particle size reduction, removal of organic solvent, and freeze-drying. The preparation method can be easily carried out at a laboratory scale. Furthermore, the same method can be employed in liposome formulation preparation in mass production, or at a commercial scale.
公开/授权文献
- US20130069261A1 METHOD AND APPARATUS FOR PREPARING NOVEL LIPOSOME 公开/授权日:2013-03-21
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