Invention Grant
US09579316B2 Salts of 2-amino-1-hydroxyethyl-8-hydroxyquinolin-2(1H)-one derivatives having both muscarinic receptor antagonist and β2 adrenergic receptor agonist activities
有权
具有毒蕈碱受体拮抗剂和β2肾上腺素能受体激动剂活性的2-氨基-1-羟乙基-8-羟基喹啉-2（1H） - 酮衍生物的盐
- Patent Title: Salts of 2-amino-1-hydroxyethyl-8-hydroxyquinolin-2(1H)-one derivatives having both muscarinic receptor antagonist and β2 adrenergic receptor agonist activities
- Patent Title (中): 具有毒蕈碱受体拮抗剂和β2肾上腺素能受体激动剂活性的2-氨基-1-羟乙基-8-羟基喹啉-2（1H） - 酮衍生物的盐
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Application No.: US14906991Application Date: 2014-07-24
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Publication No.: US09579316B2Publication Date: 2017-02-28
- Inventor: Montserrat Julia Jane , Francesc Carrera Carrera , Maria Prat Quiñones , Carlos Puig Duran , Francesca Pajuelo Lorenzo , Juan Antonio Perez Andres
- Applicant: Almirall, S.A.
- Applicant Address: ES Barcelona
- Assignee: Almirall, S.A.
- Current Assignee: Almirall, S.A.
- Current Assignee Address: ES Barcelona
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: EP13382304 20130725
- International Application: PCT/EP2014/065965 WO 20140724
- International Announcement: WO2015/011244 WO 20150129
- Main IPC: A61K31/4709
- IPC: A61K31/4709 ; A61K45/06 ; A61K9/00 ; A61K31/4725 ; C07D409/14 ; C07D275/06 ; C07C57/15 ; C07D417/14
Abstract:
The present invention is directed to crystalline addition salts of (i) 8-hydroxyquinolin-2(1H)-one derivatives and (ii) a dicarboxylic acid or a sulfimide, or a pharmaceutically acceptable solvates thereof.
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