A system and method for producing a digital image. The method may compensate for cross-talk between adjacent pixels and reduce the effect of auto-focus elements integrated into a pixel array of an image sensor. A set of coefficients is obtained, where the set of coefficients represent a relative measurement between two or more pixels in the pixel array and may be obtained from a calibration operation. A predictive function is constructed based on the set of coefficients. A compensated pixel value for at least one pixel of the image sensor is calculated using the predictive function. A digital image is created based in part on the compensated value.