Invention Grant
US09586888B2 Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
有权
苯基取代的环烷基胺作为单胺再摄取抑制剂
- Patent Title: Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
- Patent Title (中): 苯基取代的环烷基胺作为单胺再摄取抑制剂
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Application No.: US14149492Application Date: 2014-01-07
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Publication No.: US09586888B2Publication Date: 2017-03-07
- Inventor: Liming Shao , Fengjiang Wang , Scott Christopher Malcolm , Michael Charles Hewitt , Jianguo Ma , Seth Ribe , Mark A. Varney , Una Campbell , Sharon Rae Engel , Larry Wendell Hardy , Patrick Koch , Rudy Schreiber , Kerry L. Spear
- Applicant: Sunovion Pharmaceuticals Inc.
- Applicant Address: US MA Marlborough
- Assignee: SUNOVION PHARMACEUTICALS INC.
- Current Assignee: SUNOVION PHARMACEUTICALS INC.
- Current Assignee Address: US MA Marlborough
- Main IPC: C07C215/42
- IPC: C07C215/42 ; C07C217/52 ; C07C217/76 ; A61K31/135
Abstract:
Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.
Public/Granted literature
- US20140121282A1 PHENYL SUBSTITUTED CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS Public/Granted day:2014-05-01
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