Invention Grant
US09586964B2 Substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1
有权
取代的2-（4-杂环基苄基）异二氢吲哚-1-酮类似物作为毒蕈碱性乙酰胆碱受体M1的正变构调节剂
- Patent Title: Substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1
- Patent Title (中): 取代的2-（4-杂环基苄基）异二氢吲哚-1-酮类似物作为毒蕈碱性乙酰胆碱受体M1的正变构调节剂
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Application No.: US14354560Application Date: 2012-10-28
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Publication No.: US09586964B2Publication Date: 2017-03-07
- Inventor: Craig W. Lindsley , P. Jeffrey Conn , Michael R. Wood , Corey R. Hopkins , Bruce J. Melancon , Michael S. Poslusney , Darren W. Engers
- Applicant: Vanderbilt University
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Michael Best & Friedrich LLP
- International Application: PCT/US2012/062344 WO 20121028
- International Announcement: WO2013/063549 WO 20130502
- Main IPC: C07D519/00
- IPC: C07D519/00 ; C07D403/10 ; C07D487/04 ; C07D401/10 ; C07D401/14 ; C07D471/04 ; C07D417/10 ; C07D405/10 ; C07D275/06
Abstract:
In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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