Invention Grant
US09587227B2 Bacterial host strain comprising a mutant spr gene and having reduced Tsp activity
有权
细菌宿主菌株包含突变体spr基因并具有降低的Tsp活性
- Patent Title: Bacterial host strain comprising a mutant spr gene and having reduced Tsp activity
- Patent Title (中): 细菌宿主菌株包含突变体spr基因并具有降低的Tsp活性
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Application No.: US14600089Application Date: 2015-01-20
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Publication No.: US09587227B2Publication Date: 2017-03-07
- Inventor: Mark Ellis , David Paul Humphreys
- Applicant: UCB PHARMA, S.A.
- Applicant Address: BE Brussels
- Assignee: UCB PHARMA, S.A.
- Current Assignee: UCB PHARMA, S.A.
- Current Assignee Address: BE Brussels
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: GB1000587.4 20100114
- Main IPC: C12N9/04
- IPC: C12N9/04 ; C07K14/245 ; C12N9/52 ; C12N15/70
Abstract:
The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, 170, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and wherein the cell has reduced Tsp protein activity compared to a wild-type cell.
Public/Granted literature
- US20150132828A1 BACTERIAL HOST STRAIN COMPRISING A MUTANT SPR GENE AND HAVING REDUCED TSP ACTIVITY Public/Granted day:2015-05-14
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