A system and method for detecting at least one compound in a material under test (MUT) is presented. The system includes a Nuclear Quadrupole Resonance (NQR) frequency generator that generates an NQR frequency (fNQR) and propagates the fNQR frequency toward the MUT. A microwave frequency generator generates a microwave frequency (fmw) and propagates the fmw frequency toward the MUT. A RF output probe detects radio frequency (RF) emissions returned from the MUT. A detector detects the at least one compound based, at least in part, on whether the RF emissions returned from the MUT include any frequencies corresponding to fmw+/−(n×fNQR), where n is an integer of 2 or greater. In the preferred embodiment, n=2.