Aspects of the disclosure are directed to interference cancellation and wireless communication. A method of performing analog interference cancellation in a wireless communications device having a transmitter and a receiver includes receiving a reference signal representative of an interfering signal transmitted by the transmitter, selecting a first target interference type from one of a plurality of interference types affecting a an RF signal received by the receiver, configuring a first filter of an interference cancellation circuit using a coefficient computed based on the first target interference type, and cancelling interference in the RF signal using an output of the first filter. Coefficient computation may be performed in a switched manner between analog and digital domain, simultaneously in multiple domains, or in a cascaded manner that provides digital interference cancellation.