Invention Grant
- Patent Title: Substituted imidazoles as PDE10A inhibitors
- Patent Title (中): 取代的咪唑作为PDE10A抑制剂
-
Application No.: US14663706Application Date: 2015-03-20
-
Publication No.: US09592230B2Publication Date: 2017-03-14
- Inventor: Andreas Ritzen , Morten Langgard , Jan Kehler , Jacob Nielsen , John Paul Kilburn , Mohamed M. Farah
- Applicant: H. Lundbeck A/S
- Applicant Address: DK Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby
- Agency: AuerbachSchrot LLC
- Agent Jeffrey I. Auerbach
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/4985 ; C07D403/12 ; C07D471/04 ; A61K31/437 ; A61K45/06

Abstract:
This invention is directed to phenylimidazole derivatives having the formula I: wherein HET is an optionally substituted heteroaromatic group; -L- is selected from the group consisting of —CH2—CH2—, —S—CH2—, —CH2—S— and —CH═CH—, R1 is selected from the group consisting of H, C1-C6 alkyl; C1-C6 alkyl(C3-C8)cycloalkyl; C1-C6 hydroxyalkyl, CH2CN, CH2C(O)NH2, C1-C6 arylalkyl, and C1-C6 alkyl-heterocycloalkyl, and R2, R3, R4, R5 and R6 are selected individually from the group consisting of H, C1-C6 alkoxy and halogen, or pharmaceutically acceptable acid addition salts thereof, which are PDE10A enzyme inhibitors useful in the treatment of psychiatric disorders and drug addiction.
Public/Granted literature
- US20150190395A1 Novel Phenylimidazole Derivatives as PDE10A Enzyme Inhibitors Public/Granted day:2015-07-09
Information query