Invention Grant
- Patent Title: Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors
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Application No.: US14829493Application Date: 2015-08-18
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Publication No.: US09598396B2Publication Date: 2017-03-21
- Inventor: Patrick Rene Angibaud , Laurence Anne Mevellec , Bruno Roux , Pierre-Henri Storck , Christophe Meyer , Jorge Eduardo Vialard
- Applicant: Janssen Pharmaceutica NV
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Priority: EP08153432 20080327
- Main IPC: C07D221/12
- IPC: C07D221/12 ; C07D401/06 ; A61K31/4353
Abstract:
The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization and their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and Y have defined meanings.
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