![Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors](/docs/US/2017-03-21/US09598423B2/abs.jpg.600x600.jpg)
- 专利标题： Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors
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申请号： US15034217申请日： 2014-11-14
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公开(公告)号： US09598423B2公开(公告)日： 2017-03-21
- 发明人: Upender Velaparthi , Chetan Padmakar Darne , Peiying Liu , Mark D. Wittman , Bradley C. Pearce , Erika M. V. Araujo , Bireshwar Dasgupta , Jalathi Surendran Nair , Sakthi Kumaran Janakiraman , Chandrasekhar Reddy Rachamreddy , Mallikarjuna Rao Mettu , Arul Mozhi Selvan Subbiah Karuppiah , Bandreddy Subba Reddy , Pulicharla Nagalakshmi , Rajesh Onkardas Bora , Shilpa Holehatti Maheshwarappa , Selvakumar Kumaravel , Dibakar Mullick , Ramesh Sistla
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Elliott Korsen; Hong Liu
- 国际申请： PCT/US2014/065599 WO 20141114
- 国际公布： WO2015/073767 WO 20150521
- 主分类号： A61K31/498
- IPC分类号： A61K31/498 ; C07D487/04 ; C07D491/147 ; C07D487/10 ; C07D491/20 ; C07D487/20 ; C07D519/00
![Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors](/abs-image/US/2017/03/21/US09598423B2/abs.jpg.150x150.jpg)
摘要：
The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.
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