A method and system for closing an application program are provided. The method comprises: a deployment platform determining a virtual machine relevant to an application system according to configuration information of the application system when the application system is to be closed; and the deployment platform sending an indication message for closing the application system to the virtual machine relevant to the application system, wherein, the indication message for closing the application system is used for indicating the virtual machine relevant to the application system to close application programs in the application system in sequence. Through the above-mentioned technical scheme, the deployment platform indicates a virtual machine relevant to an application system required to be closed to close application programs in the application system in sequence, which makes multiple application programs of the application system deployed on multiple virtual machines can be closed in sequence.