![5-aryl-1-imino-1-oxo-[1,2,4]thiadiazines](/docs/US/2017-03-28/US09605006B2/abs.jpg.600x600.jpg)
- 专利标题： 5-aryl-1-imino-1-oxo-[1,2,4]thiadiazines
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申请号： US15105725申请日： 2014-12-17
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公开(公告)号： US09605006B2公开(公告)日： 2017-03-28
- 发明人: Wolfgang Guba , Wolfgang Haap , Andreas Kuglstatter , Jens-Uwe Peters , Ulrike Obst Sander , Christian Schnider , Roger Wermuth , Thomas Woltering
- 申请人： Hoffmann-La Roche Inc.
- 申请人地址： US NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 优先权： EP13198700 20131220
- 国际申请： PCT/EP2014/078133 WO 20141217
- 国际公布： WO2015/091595 WO 20150625
- 主分类号： C07D513/04
- IPC分类号： C07D513/04
![5-aryl-1-imino-1-oxo-[1,2,4]thiadiazines](/abs-image/US/2017/03/28/US09605006B2/abs.jpg.150x150.jpg)
摘要：
The present invention provides a compound of formula I′ having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
公开/授权文献
- US20160318952A1 5-ARYL-1-IMINO-1-OXO-[1,2,4]THIADIAZINES 公开/授权日：2016-11-03
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