- 专利标题： Composition and method for treating a tauopathy
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申请号： US12906617申请日： 2010-10-18
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公开(公告)号： US09605054B2公开(公告)日： 2017-03-28
- 发明人: Scott T. Brady , Lester I. Binder , Gerardo Andres Morfini , Nicholas M. Kanaan , Nichole E. LaPointe
- 申请人： Scott T. Brady , Lester I. Binder , Gerardo Andres Morfini , Nicholas M. Kanaan , Nichole E. LaPointe
- 申请人地址： US IL Urbana US IL Evanston
- 专利权人： The Board of Trustees of the University of Illinois,Northwestern University
- 当前专利权人： The Board of Trustees of the University of Illinois,Northwestern University
- 当前专利权人地址： US IL Urbana US IL Evanston
- 代理机构： Licata & Tyrrell P.C.
- 主分类号： C07K7/00
- IPC分类号： C07K7/00 ; A61K38/10 ; A61K39/395 ; C07K16/18 ; C07K14/47 ; G01N33/50 ; A61K38/00
摘要：
The present invention is a composition and method for the prevention and treatment of a tauopathy. The composition of the invention includes N-terminal amino acid residues of the tau protein, which have been identified as being involved in toxic activation of a PP1/GSK3 signaling cascade and inhibition of fast axonal transport in human tauopathies.
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