- Patent Title: Methods of detecting and treating stem-cell containing solid tumors
-
Application No.: US14566415Application Date: 2014-12-10
-
Publication No.: US09606124B2Publication Date: 2017-03-28
- Inventor: Max S. Wicha , Christophe Ginestier
- Applicant: The Regents of The University of Michigan
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones SC
- Agent David Staple
- Main IPC: A01N43/02
- IPC: A01N43/02 ; A01N43/16 ; A01N51/00 ; G01N33/574 ; A61K31/18 ; A61K31/337 ; A61K45/06
Abstract:
The present invention provides methods of treating cancer by administering an IL8-CXCR1 pathway inhibitor (e.g., an anti-CXCR1 antibody or Repertaxin) alone or in combination with an additional chemotherapeutic agent such that non-tumorigenic and tumorigenic cancer cells in a subject are killed. The present invention also provides compositions and methods for detecting the presence of and isolating solid tumor stem cells in a patient (e.g., based on the presence of CXCR1 or FBXO21).
Public/Granted literature
- US20150160227A1 ANTI-CXCR1 COMPOSITIONS AND METHODS Public/Granted day:2015-06-11
Information query
IPC分类:
