Invention Grant
- Patent Title: Permeable glycosidase inhibitors and uses thereof
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Application No.: US14399146Application Date: 2013-05-03
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Publication No.: US09611275B2Publication Date: 2017-04-04
- Inventor: Harold G. Selnick , Wenping Li , Eric Hostetler , Kun Liu , Ernest J. McEachern , Yuanxi Zhou , Zhongyong Wei , Changwei Mu , Yaode Wang , Jiang Chang
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: CA Burnaby, British Columbia US NJ Rahway
- Assignee: ALECTOS THERAPEUTICS, INC.,MERCK SHARP & DOHME CORP.
- Current Assignee: ALECTOS THERAPEUTICS, INC.,MERCK SHARP & DOHME CORP.
- Current Assignee Address: CA Burnaby, British Columbia US NJ Rahway
- Agent J. Eric Thies; John C. Todaro
- Priority: CNPCT/CN2012/075185 20120508
- International Application: PCT/US2013/039377 WO 20130503
- International Announcement: WO2013/169576 WO 20131114
- Main IPC: C07D513/04
- IPC: C07D513/04 ; C07B59/00 ; C07H9/06
Abstract:
The present invention is directed to compounds and pharmaceutical formulations comprising these compounds which are useful as O-linked N-acetylglucosaminidase (O-GlcNAcase) inhibitors, and thus may be useful for the treatment of certain disorders such as Alzheimer's disease including reducing NFTs and/or hyperphosphorylated tau. The invention is also directed to use of the compounds as O-GlcNAcase imaging agents.
Public/Granted literature
- US20150152127A1 PERMEABLE GLYCOSIDASE INHIBITORS AND USES THEREOF Public/Granted day:2015-06-04
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