In certain embodiments, methods and systems for multimedia data processing are provided. In an embodiment, a method for processing multimedia data includes defining one or more pixel block regions in a first cache so as to cache a plurality of reference pixel blocks corresponding to reference data. A reference pixel block from among the plurality of reference pixel blocks is assigned to a pixel block region from among the one or more pixel block regions based on a predetermined criterion. The reference pixel block is associated with a tag based on the pixel block region so as to facilitate a search of the reference data in order to process a plurality of pixel blocks associated with a multimedia frame of the multimedia data.