The present invention relates to a noise cancellation system, a headset and an electronic device. The noise cancellation system may include a loudspeaker, a first microphone, a second microphone, a housing and a processing unit. The housing may be mounted at an ear of a user, wherein the loudspeaker, the first microphone and the second microphone are installed in the housing. The processing unit may be coupled to the loudspeaker, the first microphone and the second microphone, and may be configured to generate a noise cancelling signal based on at least one of a first audio signal from the first microphone or a second audio signal from the second microphone, wherein the noise cancelling signal, when being output via the loudspeaker, at least partially compensates for environmental noise in the ear of the user.