- 专利标题: Methods of producing 7-carbon chemicals via aromatic compounds
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申请号: US14138827申请日: 2013-12-23
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公开(公告)号: US09617572B2公开(公告)日: 2017-04-11
- 发明人: Adriana Leonora Botes , Alex Van Eck Conradie , Changlin Chen , Paul S. Pearlman
- 申请人: INVISTA North America S.á r.l.
- 申请人地址: US DE Wilmington
- 专利权人: INVISTA NORTH AMERICA S.A.R.L.
- 当前专利权人: INVISTA NORTH AMERICA S.A.R.L.
- 当前专利权人地址: US DE Wilmington
- 代理机构: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- 代理商 Carla A. Mouta-Bellum
- 主分类号: C12P7/44
- IPC分类号: C12P7/44 ; C12P13/02 ; C12P7/24 ; C08G69/28 ; C12P13/00 ; C12P7/18 ; C12P7/42 ; C12N15/52
摘要:
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the anaerobic benzoyl-CoA degradation pathway enzymes.