A display device with a touch screen and a method of driving the same are provided. In a method of driving a display device including a touch screen including a plurality of sensing electrode lines and driving electrode lines and operating as an electromagnetic touch mode or a capacitive touch mode according to an input touch signal, the method includes: determining the input touch signal, controlling whether to connect pairs of sensing electrode lines among the sensing electrode lines, and controlling whether to connect pairs of driving electrode lines among the driving electrode lines, according to the touch signal.