A control information transmission and reception method based on a spatial-multiplexing gain, are provided. The control information may be transmitted by obtaining the spatial-multiplexing gain using an E-PDCCH region, and thus, a transmission efficiency of the control information may be improved. The common control information used for decoding the E-PDCCH may be transmitted via a PDCCH, and thus, a base station supporting both a general terminal and an enhanced terminal may effectively transmit the control information. Information associated with an indicator indicating whether the E-PDCCH is to be used during a subsequent resource allocation period may be transmitted, and thus, whether decoding with respect to the E-PDCCH is to be performed during the subsequent allocation period may be determined.