Invention Grant
- Patent Title: Targeting abnormal DNA repair in therapy-resistant breast and pancreatic cancers
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Application No.: US14793878Application Date: 2015-07-08
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Publication No.: US09623008B2Publication Date: 2017-04-18
- Inventor: Alan Edward Tomkinson , Feyruz Rassool
- Applicant: STC.UNM , UNIVERSITY OF MARYLAND, BALTIMORE
- Applicant Address: US NM Albuquerque US MD Baltimore
- Assignee: STC.UNM,UNIVERSITY OF MARYLAND, BALTIMORE
- Current Assignee: STC.UNM,UNIVERSITY OF MARYLAND, BALTIMORE
- Current Assignee Address: US NM Albuquerque US MD Baltimore
- Agent Henry D. Coleman; R. Neil Sudol
- Main IPC: A61K31/415
- IPC: A61K31/415 ; C40B40/06 ; A61K31/4184 ; A61K31/165 ; C12Q1/68 ; G06F19/20 ; A61K31/00
Abstract:
In one embodiment, the invention provides a method of treating a subject suffering from a breast cancer tumor which is non-responsive or intrinsically resistant to anti-estrogen therapy comprising administering a therapeutically effective amount of an inhibitor of alternative (ALT) non-homologous end joining (NHEJ) factor to the subject.In another embodiment the invention provides a method of treating a subject who suffers from a pancreatic cancer which is non-responsive to chemotherapy and/or radiation comprising co-administering a therapeutically effective amount of PARP1 inhibitor and a DNA ligase IIIα inhibitor to the subject. Related diagnostic methods, nucleic acid arrays, devices and kits are also provided.
Public/Granted literature
- US20160051517A1 TARGETING ABNORMAL DNA REPAIR IN THERAPY-RESISTANT BREAST AND PANCREATIC CANCERS Public/Granted day:2016-02-25
Information query
