Systems, methods, and computer readable media to fuse digital images are described. In general, techniques are disclosed that use multi-band noise reduction techniques to represent input and reference images as pyramids. Once decomposed in this manner, images may be fused using novel low-level (noise dependent) similarity measures. In some implementations similarity measures may be based on intra-level comparisons between reference and input images. In other implementations, similarity measures may be based on inter-level comparisons. In still other implementations, mid-level semantic features such as black-level may be used to inform the similarity measure. In yet other implementations, high-level semantic features such as color or a specified type of region (e.g., moving, stationary, or having a face or other specified shape) may be used to inform the similarity measure.