- 专利标题： Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
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申请号： US14327701申请日： 2014-07-10
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公开(公告)号： US09636306B2公开(公告)日： 2017-05-02
- 发明人: Isa Odidi , Amina Odidi
- 申请人： Isa Odidi , Amina Odidi
- 申请人地址： CA Toronto, Ontario
- 专利权人： INTELLIPHARMACEUTICS CORP.
- 当前专利权人： INTELLIPHARMACEUTICS CORP.
- 当前专利权人地址： CA Toronto, Ontario
- 代理机构： Thomas Horstemeyer, LLP
- 主分类号： A61K9/48
- IPC分类号： A61K9/48 ; A61K9/20 ; A61K9/28 ; A61K31/00 ; A61K31/44 ; A61K31/4439 ; A61K45/06 ; A61K31/4184 ; A61K31/435 ; A61K9/16 ; A61K9/50
摘要：
An oral pharmaceutical composition comprises multiple populations of at least one of beads, pellets, tablets and granules provided in a capsule, the composition comprising: a first population of a pharmaceutical active comprising a pharmaceutical active substance releasable at a first rate; a population of a basic substance; and a second population of a pharmaceutical active comprising a pharmaceutical active substance releasable at a second rate. In another embodiment, the oral pharmaceutical composition comprises multiple populations of at least one of beads, pellets, tablets and granules provided in a capsule, the composition comprising: a population of a pharmaceutical active; a population of a basic substance; a population of enteric coated pharmaceutical active; and a population of enteric coated basic substance. The composition can provide multiple site specific delivery of a pharmaceutical active in a rapid, delayed and/or sustained release manner into the plasma.
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