- 专利标题: Quinoline carboxamide and quinoline carbonitrile derivatives as mGluR2-negative allosteric modulators, compositions, and their use
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申请号: US15047224申请日: 2016-02-18
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公开(公告)号: US09636337B2公开(公告)日: 2017-05-02
- 发明人: Christopher James Bungard , Antonella Converso , Pablo De Leon , Barbara Hanney , Timothy John Hartingh , Jesse Josef Manikowski , Peter J. Manley , Robert Meissner , Zhaoyang Meng , James J. Perkins , Michael T. Rudd , Youheng Shu
- 申请人: Merck Sharp & Dohme Corp
- 申请人地址: US NJ Rahway
- 专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人地址: US NJ Rahway
- 代理商 Keith D. MacMillan; John C. Todaro
- 主分类号: A61K31/47
- IPC分类号: A61K31/47 ; A61K31/506 ; A61K31/4985 ; A61K31/496 ; A61K31/4709 ; A61K31/541 ; A61K31/5377 ; C07D401/14 ; C07D413/14 ; C07D215/48 ; C07D401/04 ; C07D401/06 ; C07D409/04 ; C07D413/06 ; C07D417/06 ; C07D417/14 ; C07D471/04 ; C07D491/10
摘要:
The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (I) wherein ring A, RQ, -L-, R1, n, R2, and R3 are as defined herein. The compounds of the invention are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and in methods of treating a patient (preferably a human) for diseases or disorders in which the mGluR2-NAM receptor is involved, including potentially Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders, by administering to the patient a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof. The invention is also directed to pharmaceutical compositions comprising a compound of the invention, or a pharmaceutically acceptable salt thereof, (optionally in combination with one or more additional active ingredients), and a pharmaceutically acceptable carrier, and the use of the compounds and pharmaceutical compositions of the invention in the treatment of such diseases.
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