- 专利标题： Amplification of oligonucleotides containing non-standard nucleotides by polymerase chain reactions
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申请号： US14746243申请日： 2015-06-22
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公开(公告)号： US09637783B1公开(公告)日： 2017-05-02
- 发明人: Steven Benner , Roberto Laos , Nicole Leal , Nilesh Karalkar , Zunyi Yang
- 申请人： Steven Benner , Roberto Laos , Nicole Leal , Nilesh Karalkar , Zunyi Yang
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12P19/34 ; C12N9/12
摘要：
This invention relates to processes that amplify, in a polymerase chain reaction architecture, oligonucleotide analogs that incorporate non-standard nucleobase analogs from an artificially expanded genetic information system. These pair in DNA duplexes via patterns of hydrogen bonds that are different from patterns that join the thymine-adenine and guanine-cytosine nucleobase pairs.
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