A headphone wireless expansion device for switching among multiple targets is connected to an information device to receive audio data which is then transmitted to a headphone for playing. The headphone wireless expansion device includes multi-target connection data and an audio control mechanism. The multi-target connection data includes a plurality of device identification codes, a plurality of device authorization codes corresponding to a plurality of information devices respectively, and a plurality of audio tags corresponding to the device identification codes and the device authorization codes respectively. The audio control mechanism searches the audio tag having audio features same as that of the unrecognized audio signal, and reads the corresponding device identification code and device authorization code. The headphone wireless expansion device enables a conventional wired headphone to wirelessly connect with the information device and switch among multiple information devices via a voice control method through identifying the audio tag.