A process for calibrating and evaluating a machine-vision vehicle wheel alignment system having front and rear imaging components associated with each of the left and right sides of a vehicle support structure. Each pair of imaging components defines a front and rear field of view, with a common overlapping region associated with each respective side of the vehicle support structure. Optical targets disposed within each of the overlapping field of view regions are observed by the imaging components to establish performance ratings for the system as a whole, for groups of components within the system, and for individual components within the system.