According to one aspect, the subject matter described herein includes a method for routing Diameter messages. The method includes steps occurring at a Diameter signaling router (DSR) comprising a plurality of Diameter message processors. The method includes receiving a Diameter request message. The method further includes generating a hop-by-hop identifier for identifying a first Diameter message processor of the plurality of Diameter message processors. The method further includes incorporating the hop-by-hop identifier into the Diameter request message. The method further includes routing the Diameter request message to a first Diameter node.