The present invention relates to a method of transmitting and receiving data in soft handoff of a wireless communication system. According to an aspect of the present invention, in the method of receiving data in soft handoff of a wireless communication system, a mobile station receives a first sequence being generated by interleaving transmission data using a first interleaver pattern, and also receives a second sequence being generated by interleaving the transmission data using a second interleaver pattern. Then, the mobile station combines and decodes the first sequence and the second sequence before receiving an entire frame having the first sequence allocated thereto.