- 专利标题： Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors
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申请号： US14829527申请日： 2015-08-18
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公开(公告)号： US09649301B2公开(公告)日： 2017-05-16
- 发明人: Peter Crooks , Linda Dwoskin , Guangrong Zheng , Sangeetha Sumithran , David Allen , Zhenfa Zhang , Paul Lockman
- 申请人： University of Kentucky Research Foundation
- 申请人地址： US KY Lexington
- 专利权人： University of Kentucky Research Foundation
- 当前专利权人： University of Kentucky Research Foundation
- 当前专利权人地址： US KY Lexington
- 代理机构： Crowell & Moring LLP
- 主分类号： A61K31/439
- IPC分类号： A61K31/439 ; A61K31/395 ; C07D471/16 ; C07D471/06
摘要：
Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
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