发明授权
- 专利标题： Methods for producing stable therapeutic formulations in aprotic polar solvents
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申请号： US15136650申请日： 2016-04-22
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公开(公告)号： US09649364B2公开(公告)日： 2017-05-16
- 发明人: Steven Prestrelski , Michael Sandoval , Martin Donovan
- 申请人： Xeris Pharmaceuticals, Inc.
- 申请人地址： US TX Austin
- 专利权人： XERIS PHARMACEUTICALS, INC.
- 当前专利权人： XERIS PHARMACEUTICALS, INC.
- 当前专利权人地址： US TX Austin
- 代理机构： Norton Rose Fulbright US LLP
- 主分类号： A61K38/26
- IPC分类号： A61K38/26 ; C07K14/605 ; A61P3/00 ; A61K47/02 ; A61K47/20 ; A61K47/10 ; A61K47/26 ; A61K9/00
摘要：
Certain embodiments are directed to a formulation of a therapeutic agent, as well as a method of making such a formulation, comprising at least one therapeutic agent dissolved in an aprotic polar solvent system comprising at least one ionization stabilizing excipient in a concentration sufficient to impart physical and chemical stability to the therapeutic agent.
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