The described embodiments relate generally to skip fire control of internal combustion engines and particularly to mechanisms for determining a desired operational firing fraction. In some embodiments, a firing fraction determining unit is arranged to determine a firing fraction suitable for delivering a requested engine output. The firing fraction determining unit may utilize data structures such as lookup tables in the determination of the desired firing fraction. In one aspect the desired engine output and one or more operational power train parameters such as current engine speed, are used as indices to a lookup table used to select a desired firing fraction. In other embodiments, additional indices to the data structure may include any one of: transmission gear; manifold absolute pressure (MAP); manifold air temperature; a parameter indicative of mass air charge (MAC); cam position; cylinder torque output; maximum permissible manifold pressure; vehicle speed; and barometric pressure.