Embodiments of the present invention relate to a method and an apparatus for processing signal interference, including: splitting a first self-interference signal into at least two same sub self-interference signals, adjusting amplitudes and phases of the sub self-interference signals to obtain adjusted sub-signals, superposing the adjusted sub-signals and received signals, to obtain superposed sub-signals, filtering the superposed sub-signals by using filters of corresponding channels, to obtain wanted sub-signals, and merging each of the wanted sub-signals to obtain a complete wanted signal. Because received signals are separately filtered by using n different channels, it can be implemented that a self-interference signal can be effectively filtered out on each frequency band.