Various aspects provide systems and methods for optimizing hardware monitoring on a computing device. A computing device may receive a monitoring request to monitor a portion of code or data within a process executing on the computing device. The computing device may generate from the monitoring request a first monitoring configuration parameter for a first hardware monitoring component in the computing device and may identify a non-optimal event pattern that occurs while the first hardware monitoring component monitors the portion of code or data according to the first monitoring configuration parameter. The computing device may apply a transformation to the portion of code or data and reconfigure the first hardware monitoring component by modifying the first monitoring configuration parameter in response to the transformation of the portion of code or data.