Invention Grant
- Patent Title: Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis
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Application No.: US14364759Application Date: 2012-12-17
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Publication No.: US09663521B2Publication Date: 2017-05-30
- Inventor: Kevin Frankowski , Samarjit Patnaik , Sui Huang , Juan Jose Marugan , John Norton , Frank J. Schoenen , Noel Terrence Southall , Steven Titus , Wei Zheng
- Applicant: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , UNIVERSITY OF KANSAS , NORTH-WESTERN UNIVERSITY
- Applicant Address: US DC Washington US KS Lawrence US IL Evanston
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services,University of Kansas,Northwestern University
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services,University of Kansas,Northwestern University
- Current Assignee Address: US DC Washington US KS Lawrence US IL Evanston
- Agency: Leydig, Voit & Mayer, Ltd.
- International Application: PCT/US2012/070155 WO 20121217
- International Announcement: WO2013/090912 WO 20130620
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; A61K31/695 ; A61K45/06 ; C07F7/18 ; A61P35/02 ; A61P35/04
Abstract:
The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.
Public/Granted literature
- US20140323438A1 COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS Public/Granted day:2014-10-30
Information query
