A machine tool has a multiplicity of stationary tool spindles that are optionally displaceable from a retracted rest position into an extended working position are positioned at various positions in a frame-like stand which defines and comprises machining space, and has a workpiece manipulator by way of which a workpiece support is movable multi-axially in translation and preferably also in rotation. In order to create advantageous loading conditions, it proposed that a loading door is associated with at least one of the leg walls defining the machining space, and that a workpiece support holder, which is equipped with a coupling for the workpiece support, is arranged on at least one, preferably on both, loading door panel fronts.