- 专利标题: Bright fluorochromes based on multimerization of fluorescent dyes
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申请号: US14723505申请日: 2015-05-28
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公开(公告)号: US09670318B2公开(公告)日: 2017-06-06
- 发明人: Christian Dose
- 申请人: Miltenyi Biotec GmbH
- 申请人地址: DE Bergisch Gladbach
- 专利权人: Miltenyi Biotec GmbH
- 当前专利权人: Miltenyi Biotec GmbH
- 当前专利权人地址: DE Bergisch Gladbach
- 代理商 Jaquelin K. Spong
- 主分类号: C08G65/48
- IPC分类号: C08G65/48
摘要:
The invention is directed to a fluorescent dye according to the general formula I: with C is a core moiety comprising 20 to 200 atoms; S same or different ether residues comprising 1 to 10 carbon atoms; n is an integer ranging from 2 to 500; m is an integer ranging from 0 to 500; x is an integer ranging from 2 to 50; y is an integer ranging from 1 to 50; R same or different residue comprising a reactive group capable of forming a covalent bond with a biomolecule; F same or different fluorophores covalently bound to (S)n. The fluorescent dyes can be conjugated to a biomolecule and used for flow cytometry and/or by fluorescence microscopy.
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