A method for pilot signal based self-interference cancellation tuning includes detecting a tuning trigger and in response to the tuning trigger, generating a pilot transmit signal according to the trigger data; and transmitting, at the transmitter, the pilot transmit signal; receiving, at the receiver, a pilot receive signal; cancelling, at the self-interference canceller, a portion of self-interference in the receive pilot signal, resulting in a composite pilot signal; analyzing the composite pilot signal; and tuning a configuration parameter of the self-interference canceller, based on analysis of the composite pilot signal, resulting in reduced self-interference in the composite pilot signal.