Invention Grant
- Patent Title: Biodegradable stealth polymeric particles fabricated using the macromonomer approach by free radical dispersion polymerization
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Application No.: US14575517Application Date: 2014-12-18
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Publication No.: US09675556B2Publication Date: 2017-06-13
- Inventor: Emmanuel Oyekanmi Akala , Simeon Kolawole Adesina
- Applicant: Howard University
- Applicant Address: US DC Washington
- Assignee: Howard University
- Current Assignee: Howard University
- Current Assignee Address: US DC Washington
- Agency: Fitch, Even, Tabin & Flannery, LLP
- Main IPC: B01J13/06
- IPC: B01J13/06 ; B01J13/16 ; A61K9/16 ; A61K31/337 ; A61K31/704 ; B82Y5/00 ; B82Y15/00 ; B82Y40/00 ; A61K9/51 ; C08G63/85

Abstract:
The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-lactate) that is crosslinked by at least one hydrolysable monomer. Another embodiment of the present invention is a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent. Another embodiment of the present invention is a polymer particle comprising, a crosslinked copolymer comprises structures represented by Formulas (I), (II), and (III), where Formulas (I), (II) and (III) are defined in the specification. Yet other embodiments of the present invention include a method of preparing a methacrylate terminated macromonomer, a method of preparing a crosslinking agent, and a method of preparing a therapeutic agent loaded nanosphere by dispersion polymerization.
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