![Pyrrolo[2,3-D]pyrimidine derivatives, process for their preparation and their use as kinase inhibitors](/docs/US/2017-06-20/US09682083B2/abs.jpg.600x600.jpg)
- 专利标题： Pyrrolo[2,3-D]pyrimidine derivatives, process for their preparation and their use as kinase inhibitors
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申请号： US14889987申请日： 2014-05-07
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公开(公告)号： US09682083B2公开(公告)日： 2017-06-20
- 发明人: Mauro Angiolini , Laura Buffa , Maria Menichincheri , Ilaria Motto , Paolo Polucci , Gabriella Traquandi , Fabio Zuccotto
- 申请人： NERVIANO MEDICAL SCIENCES S.R.L.
- 申请人地址： IT Nerviano
- 专利权人： NERVIANO MEDICAL SCIENCES S.R.L.
- 当前专利权人： NERVIANO MEDICAL SCIENCES S.R.L.
- 当前专利权人地址： IT Nerviano
- 代理机构： Silvia Salvadori, P.C.
- 代理商 Silvia Salvadori
- 优先权： EP13167606 20130514
- 国际申请： PCT/EP2014/059342 WO 20140507
- 国际公布： WO2014/184069 WO 20141120
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; A61K45/06 ; A61K31/496 ; C07D487/04
![Pyrrolo[2,3-D]pyrimidine derivatives, process for their preparation and their use as kinase inhibitors](/abs-image/US/2017/06/20/US09682083B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to 6-amino-7-deaza-purine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.