Invention Grant
- Patent Title: Fibrinogen preparations enriched in fibrinogen with an extended alpha chain
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Application No.: US14877354Application Date: 2015-10-07
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Publication No.: US09694054B2Publication Date: 2017-07-04
- Inventor: Joseph Grimbergen , Jacob Koopman , Abraham Bout
- Applicant: Mallinckrodt Pharma IP Trading D.A.C.
- Applicant Address: IE Dublin
- Assignee: Mallinckrodt Oharma IP Trading D.A.C.
- Current Assignee: Mallinckrodt Oharma IP Trading D.A.C.
- Current Assignee Address: IE Dublin
- Priority: NL10150391 20100108
- Main IPC: C12Q1/56
- IPC: C12Q1/56 ; C12P21/04 ; A61K38/00 ; C07K14/75 ; A61K38/36 ; C12P21/00
Abstract:
The present invention relates to fibrinogen preparations enriched in α-extended fibrinogen. Compositions comprising such preparations show improved clotting properties compared to preparations based on HMW Fib which typically contain no or only low amounts of α-extended fibrinogen. In particular, clot formation time and the clot strength of a clot made by α-extended fibrinogen are improved. In addition, plasmin-mediated degradation of α-extended fibrinogen is reduced as compared to plasma derived fibrinogen.
Public/Granted literature
- US20160158323A1 Fibrinogen Preparations Enriched in Fibrinogen With An Extended Alpha Chain Public/Granted day:2016-06-09
Information query
