Invention Grant
- Patent Title: Glycosidase inhibitors and uses thereof
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Application No.: US14439790Application Date: 2013-10-30
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Publication No.: US09695197B2Publication Date: 2017-07-04
- Inventor: Ramesh Kaul , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Qun Dang , Harold G. Selnick
- Applicant: Alectos Therapeutics Inc. , Merck Sharp & Dohme Corp.
- Applicant Address: CA Burnaby US NY Rahway
- Assignee: Alectos Therapeutics Inc.,Merck Sharp & Dohme Corp.
- Current Assignee: Alectos Therapeutics Inc.,Merck Sharp & Dohme Corp.
- Current Assignee Address: CA Burnaby US NY Rahway
- Agency: Clark & Elbing LLP
- International Application: PCT/CA2013/050822 WO 20131030
- International Announcement: WO2014/067003 WO 20140508
- Main IPC: C07D498/04
- IPC: C07D498/04 ; C07D513/04 ; C07H9/06
Abstract:
The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Public/Granted literature
- US20150291620A1 GLYCOSIDASE INHIBITORS AND USES THEREOF Public/Granted day:2015-10-15
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