This disclosure pertains to systems, methods, and computer readable media for performing lens shading correction (LSC) operations that modulate gains based on scene lux level and lens focus distance. These gains compensate for both color lens shading (i.e., the deviation between R, G, and B channels) and vignetting (i.e., the drop off in pixel intensity around the edges of an image). As scene illuminance increases, the sensor captures more signal from the actual scene, and the lens shading effects begin to appear. To deal with the situation, the lens shading gains are configured to adaptively ‘scale down’ when scene lux approaches zero and ‘scale up’ when scene lux changes from near zero to become larger. The lens shading gain may also be modulated based on the focus distance. For optical systems without zoom, the inventors have discovered that the amount of lens shading fall off changes as focus distance changes.